Tudy in glucose homeostasis, lipid metabolism and therapeutic method. Arq Bras Endocrinol Metabol 2007; 51: 52633. 32. Michael DR, Ashlin TG, Buckley ML, Ramji DP. Liver X receptors, atherosclerosis and inflammation. Curr Atheroscler Rep 2012; 14: 28493. 33. Weber C, Noels H. Atherosclerosis: existing pathogenesis and therapeutic selections. Nat Med 2011; 17: 1410422. 34. Westerterp M, Bochem AE, Yvan-Charvet L, Murphy AJ, Wang N, Tall AR. ATP-binding cassette transporters, atherosclerosis, and inflammation. Circ Res 2014; 114: 15770. 35. McMurray HF, Parrott DP, Bowyer DE. A standardised technique of culturing aortic explants, appropriate for the study of variables affecting the phenotypic modulation, migration and proliferation of aortic smooth muscle cells. Atherosclerosis 1991; 86: 22737. 36. Xue JH, Yuan Z, Wu Y, Liu Y, Zhao Y, Zhang WP et al. High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance. Cardiovasc Res 2010; 86: 14150.Cell Death and Illness is an open-access journal published by Nature Publishing Group. This operate is licensed under a Inventive Commons Attribution four.0 International Licence. The photos or other third celebration material within this report are included in the article’s Inventive Commons licence, unless indicated otherwise inside the credit line; in the event the material will not be incorporated beneath the Creative Commons licence, users will want to receive permission from the licence holder to reproduce the material.Buy2-Hydroxy-4-(hydroxymethyl)benzaldehyde To view a copy of this licence, visit http://creativecommons.1211581-13-3 manufacturer org/licenses/by/4.PMID:24278086 Cell Death and Disease
Dong et al. Virology Journal (2017) 14:180 DOI ten.1186/s12985-017-0842-RESEARCHOpen AccessCharacteristics of influenza H13N8 subtype virus firstly isolated from Qinghai Lake Area, ChinaJie Dong, Hong Bo, Ye Zhang, Libo Dong, Shumei Zou, Weijuan Huang, Jia Liu, Dayan Wang* and Yuelong Shu*AbstractBackground: Since the hugely pathogenic H5N1 influenza caused a huge number of deaths of wild bird within this region in 2005, Qinghai Lake in China has develop into a hot spot for study from the influence of avian influenza to migratory wild birds. On the other hand, the ecology and evolution of low pathogenic avian influenza virus in this region are limited. This project-based avian influenza surveillance in Qinghai lake area was initiated in year 2012. Strategy: Samples of wild bird feces and lake surface water were collected in Qinghai Lake in year 2012.Virus isolation was performed on embryonated chicken eggs. The influenza A virus was determined by rRT-PCR. Virus sequences were acquired by deep sequencing. The phylogenetic correlation and molecular traits of the viruses had been analyzed. The virus growth and infection characteristics, receptor binding preference were studied, and pathogenicity in vitro as well as. Outcomes: Two H13N8 subtype influenza viruses were isolated. The viruses are phylogenetically belong to Eurasian lineage. Most of the genes are connected with gull origin influenza virus except PB1 gene, which can be most in all probability derived from Anseriformes virus. The proof of interspecies reassortment was presented. The two viruses have restricted growth capacity on MDCK and A549 cells while grow effectively in embryonated eggs. The dual receptor binding attributes with the two viruses was shown up. The low pathogenic attributes had been determined by trypsin dependence plaque formation assay. Conclusions: The two H13N8 subtype influenza viruses are highly connected with gull origin. The interspe.
